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Jeffrey A Kline Selected Research

Pulmonary Embolism

12/2022An adaptive clinical trial design to identify the target dose of tenecteplase for treatment of acute pulmonary embolism.
1/2022Ruling out pulmonary embolism across different healthcare settings: A systematic review and individual patient data meta-analysis.
1/2022Modulation of soluble guanylate cyclase ameliorates pulmonary hypertension in a rat model of chronic thromboembolic pulmonary hypertension by stimulating angiogenesis.
1/2021Outpatient Treatment of Low-risk Pulmonary Embolism in the Era of Direct Oral Anticoagulants: A Systematic Review.
1/2021Monotherapy Anticoagulation to Expedite Home Treatment of Patients Diagnosed With Venous Thromboembolism in the Emergency Department: A Pragmatic Effectiveness Trial.
11/2020Fibrinolytics for the treatment of pulmonary embolism.
1/2020Inhaled nitric oxide to control platelet hyper-reactivity in patients with acute submassive pulmonary embolism.
1/2020Over-Testing for Suspected Pulmonary Embolism in American Emergency Departments: The Continuing Epidemic.
1/2020Effect of metabolic syndrome on mean pulmonary arterial pressures in patients with acute pulmonary embolism treated with catheter-directed thrombolysis.
1/2019Inhaled nitric oxide to treat intermediate risk pulmonary embolism: A multicenter randomized controlled trial.
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Jeffrey A Kline Research Topics

Disease

59Pulmonary Embolism
12/2022 - 02/2002
18Venous Thromboembolism
01/2022 - 05/2005
16Sepsis (Septicemia)
12/2018 - 06/2003
13Septic Shock (Toxic Shock Syndrome)
12/2018 - 06/2003
12Inflammation (Inflammations)
12/2017 - 08/2006
9Chest Pain (Chest Pains)
01/2021 - 07/2006
8Pulmonary Hypertension
01/2022 - 08/2006
7Ischemia
01/2016 - 05/2003
7Shock
10/2015 - 07/2007
7Infections
06/2013 - 08/2007
6Neoplasms (Cancer)
01/2022 - 04/2010
6Venous Thrombosis (Deep-Vein Thrombosis)
01/2021 - 04/2010
6Dyspnea (Shortness of Breath)
01/2019 - 03/2014
6Hemorrhage
01/2018 - 04/2002
5Hemolysis
07/2017 - 12/2011
5Hypotension (Low Blood Pressure)
07/2013 - 01/2004
4Renal Insufficiency (Renal Failure)
01/2022 - 01/2010
4Acute Coronary Syndrome
01/2021 - 07/2006
4Heart Arrest (Cardiac Arrest)
01/2019 - 04/2002
3Thrombosis (Thrombus)
01/2022 - 05/2010
3COVID-19
01/2022 - 01/2021
3Cardiovascular Diseases (Cardiovascular Disease)
01/2021 - 06/2012
3Hypertension (High Blood Pressure)
01/2020 - 11/2003
2Respiratory Insufficiency (Respiratory Failure)
01/2022 - 11/2009
2Intracranial Hemorrhages (Intracranial Hemorrhage)
04/2018 - 05/2015
2Thromboembolism
04/2018 - 02/2010
2Heart Failure
01/2018 - 11/2003
2Right Ventricular Dysfunction
07/2017 - 02/2015
2Necrosis
01/2017 - 10/2003
2Wounds and Injuries (Trauma)
10/2012 - 06/2010
2Hypoxia (Hypoxemia)
04/2010 - 06/2008
2Fatigue
06/2007 - 05/2003
1Pathologic Constriction (Stenosis)
01/2021
1Coronary Stenosis (Coronary Artery Stenosis)
01/2021

Drug/Important Bio-Agent (IBA)

18fibrin fragment D (D-dimer)IBA
01/2022 - 02/2002
16Lactic Acid (Lactate)FDA LinkGeneric
12/2018 - 05/2003
10Biomarkers (Surrogate Marker)IBA
12/2017 - 11/2006
7AnticoagulantsIBA
01/2021 - 05/2012
74- ((1,4,8,11- tetraazacyclotetradec- 1- yl)methyl)benzoic acidIBA
01/2020 - 05/2010
6Proteins (Proteins, Gene)FDA Link
01/2014 - 06/2003
5Vitamin KFDA Link
01/2021 - 02/2016
5RivaroxabanIBA
01/2018 - 07/2015
5Hemoglobins (Hemoglobin)IBA
02/2016 - 12/2011
5ChemokinesIBA
03/2010 - 11/2003
4TenecteplaseFDA Link
12/2022 - 04/2007
4Nitric Oxide (Nitrogen Monoxide)FDA Link
01/2020 - 06/2014
4Brain Natriuretic Peptide (Natrecor)FDA Link
01/2019 - 11/2003
4Heparin (Liquaemin)FDA LinkGeneric
07/2015 - 01/2006
3Soluble Guanylyl CyclaseIBA
01/2022 - 12/2011
3ORALIT (ORS)IBA
01/2022 - 10/2015
3Polystyrenes (Polystyrene)IBA
01/2022 - 06/2003
3TroponinIBA
01/2021 - 08/2008
3Carbon DioxideIBA
01/2019 - 07/2006
3Carnitine (L-Carnitine)FDA LinkGeneric
12/2018 - 08/2014
3Glucose (Dextrose)FDA LinkGeneric
12/2018 - 06/2008
3cytidylyl-(3'-5')-cytidine (CpC)IBA
01/2018 - 05/2014
3Anti-Bacterial Agents (Antibiotics)IBA
05/2017 - 09/2011
3Oxygen (Dioxygen)IBA
01/2017 - 07/2006
3Tissue Plasminogen Activator (Alteplase)FDA Link
01/2016 - 04/2007
3Peroxidase (Myeloperoxidase)IBA
02/2010 - 07/2006
2Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
01/2020 - 01/2016
2Fatty Acids (Saturated Fatty Acids)IBA
12/2018 - 06/2008
2Prothrombin (Factor II)IBA
04/2018 - 06/2006
2ProcalcitoninIBA
05/2017 - 07/2007
2salicylhydroxamic acid (SHAM)IBA
05/2015 - 02/2010
2EnzymesIBA
02/2015 - 06/2008
2Saline SolutionIBA
08/2014 - 05/2003
2Arginine (L-Arginine)FDA Link
03/2014 - 02/2012
2HaptoglobinsIBA
01/2014 - 07/2012
2BAY 41-8543IBA
04/2013 - 12/2011
2Troponin IIBA
06/2012 - 07/2007
2CreatinineIBA
06/2012 - 01/2010
2ArginaseIBA
02/2012 - 08/2011
2Estrogens (Estrogen)FDA Link
06/2010 - 04/2010
2Pharmaceutical PreparationsIBA
09/2009 - 05/2003
2C-Reactive ProteinIBA
09/2008 - 07/2006
2Pyruvic Acid (Pyruvate)IBA
06/2007 - 05/2003
2Oxidoreductases (Dehydrogenase)IBA
06/2007 - 05/2003
1Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
01/2022
1Nucleic AcidsIBA
01/2022
1Semaxinib (SU5416)IBA
01/2022
1Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA
01/2022
1Coloring Agents (Dyes)IBA
11/2020
1Fibrinolytic Agents (Antithrombotic Agents)IBA
11/2020

Therapy/Procedure

17Therapeutics
01/2022 - 08/2005
13Resuscitation
01/2019 - 04/2002
8Microspheres (Microsphere)
01/2022 - 04/2002
7Length of Stay
01/2022 - 11/2004
3Induced Hypothermia
01/2019 - 01/2018
3Early Goal-Directed Therapy
06/2011 - 08/2007
3Ligation
10/2003 - 05/2003
2Artificial Respiration (Mechanical Ventilation)
01/2022 - 10/2015
2Airway Management
12/2012 - 08/2012
2Intravenous Injections
02/2010 - 04/2002
2Punctures
06/2003 - 04/2002
1Thrombolytic Therapy
12/2022
1Aftercare (After-Treatment)
01/2022
1Renal Replacement Therapy (Therapies, Renal Replacement)
01/2022
1Noninvasive Ventilation
01/2022
1Mechanical Ventilators (Ventilator)
01/2021